Enamel, Reimagined: Between Promise, Proof, and the Human Need to Believe
DOI:
https://doi.org/10.17159/Keywords:
remineralisation, regenerativeAbstract
I was recently confronted with the question from a curious young patient: “why can’t teeth heal themselves the way skin
does?” I suspect it is a question every clinician hears at some point, sometimes from a child bewildered by their first cavity,
sometimes from an adult facing years of cumulative enamel loss. And if we are honest, it is a question that unsettles even some of us. Why can’t enamel regenerate? Why does the hardest tissue in the human body have no capacity for repair beyond remineralisation at its surface? While for some the answer is obvious and any discussion on this is without
value, however, what if…
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References
1. Pandya M, Diekwisch TGH. Enamel biomimetics—fiction or future of dentistry. Int J Oral Sci. 2019; 11(1):8. doi:10.1038/s41368-018-0038-6
2. Gamea S, Radvar E, Athanasiadou D, et al. Biomimetic mineralization of keratin scaffolds for enamel regeneration. Adv Healthc Mater. 2025; 14(30):e02465. doi:10.1002/ adhm.202502465
3. Shao C, Jin B, Mu Z, et al. Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth. Sci Adv. 2019; 5(8):eaaw9569. doi:10.1126/sciadv. aaw9569
4. Kwak SY, Litman A, Margolis HC, Yamakoshi Y, Simmer JP. Biomimetic enamel regeneration mediated by leucine-rich amelogenin peptide. J Dent Res. 2017; 96(5):524– 30. doi:10.1177/0022034516688659
5. Ruan Q, Zhang Y, Yang X, Nutt S, Moradian-Oldak J. An amelogenin–chitosan matrix promotes assembly of an enamel-like layer with a dense interface. Acta Biomater. 2013; 9(7):7289–97. doi:10.1016/j.actbio.2013.04.004
6. Mukherjee K, Ruan Q, Liberman D, White SN, Moradian-Oldak J. Amelogenin peptide–chitosan hydrogel for biomimetic enamel regrowth. Front Dent Med. 2021; 2:697544. doi:10.3389/fdmed.2021.697544
7. Peters HP, Dunwoody S, Allgaier J, Lo YY, Brossard D. Public communication ofscience 2.0. Sci Commun. 2014;36(2):123–48. doi:10.1177/1075547013520221
8. Sharot T. The optimism bias. Curr Biol. 2011; 21(23):R941–5. doi:10.1016/j.cub.2011.10.030
9. Tversky A, Kahneman D. Availability: A heuristic for judging frequency and probability.Cogn Psychol. 1973; 5(2):207–32.
10. Koehler JJ. The influence of prior beliefs on scientific judgments of evidence quality.Organ Behav Hum Decis Process. 1993;56(1):28–55.
11. McCabe DP, Castel AD. Seeing is believing: The effect of brain images on judgments of scientific reasoning. Cognition. 2008; 107(1):343–52. doi:10.1016/j.cognition.2007.07.017
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