Dentinogenic Ghost Cell Tumour, a rare case of an African young female patient: Review of literature and report of a case


  • M Lamola Limpopo Department of Health, WF Knobel Hospital, General Dentistry. South Africa.
  • MMJ Masilela Sefako Makgatho Health Sciences University, Department of Oral and Maxillofacial Surgery, Pietersburg Academic Hospital, Oral Pathology Unit. South Africa
  • TO Adedoja Implantology. Mankweng Hospital, General Dentistry. South Africa.



Dentinogenic ghost cell tumour, Ghost cells, Maxilla


Dentinogenic ghost cell tumour (DGCT) is a very rare aggressive benign odontogenic tumour with high recurrence rate and a potential to transform into malignancy. It can render facial disfigurement. The tumour is most frequently encountered in males than females with a ratio of 2:1. The peak incidence is in patients aged 40 - 60 years and the posterior mandible is slightly more affected than the maxilla. Segmental resection is a recommended surgical treatment and long-term postsurgical follow up is essential. This paper discusses a case of a 20-year-old African female patient who was diagnosed with a DGCT.


Download data is not yet available.


Metrics Loading ...


Carlos R, Ledesma-Montes C. Dentinogenic ghost cell tumour in The fourth edition of the head and neck World Health Organization. Adel K El-Naggar, John KC Chan, Jennfer R. Grandis, Takashi Takata, Pieter J Slootweg, WHO classification of head and neck tumours. LYON. IARC press, 2017: 226-227

Gorlin RJ, Pindborg JJ, Odont, Clausen FP, Vickers A. The calcifying odontogenic cyst-a possible analogue of the cutaneous calcifying epithelioma of Malherbe. An analysis of fifteen cases. Oral Surg Oral Med Oral Pathol. 1962; 15: 1235-43

Pinheiro TN, de Souza APF, Bacchi CE, Consolaro A. Dentinogenic ghost cell tumor: A bibliometric review of literature. Journal of Oral Disease Markers. 2019; 3: 9-17

Buchner A. The central (intraosseous) calcifying odontogenic cyst: An analysis of 215 cases. J Oral Maxillofac Surg. 1991; 49: 330-9.

Walia C, Kashyap B, Roy S. Disorganized histomorphology: Dentinogenic ghost cell tumor. J Oral Maxillofac Pathol. 2017; 21: 154 –77.

Mamabolo MM, Noffke C, Raubenheimer E. Odontogenic tumours in the first two decades of life in a rural African population sample: A 26

year retrospective analysis. Dentomaxillofacial Radiology. 2011; 40: 331-37

Okoh DS, Akinshipo AO, Butali A, Omitola OG, Sigbeku OF, Soyele OO et al. Descriptive Epidemiology of Odontogenic Tumors in Nigeria:

Ar African Oral Pathology Research Consortium Multicenter Study. Niger J Clin Prac. 2020; 23: 1695-701

Singh K, Simon ENM, Mwalutambi S, Owibingire SS. A prospective Study on Odontogenic Tumours among Patients Attending Muhibili

National Hospital, Dar Es Salaam, Tanzania. Oral Rehabilitation and Dentistry. 2020; 3(1): 2-6

Ogundana OM, Effiom OA, Odukoya O. Pattern of distribution of odontogenic tumours in SubSaharan African. International Dental Journal. 2017; 67: 308-17

Jing W, Xuan M, Lin Y, Wu L, Liu L, Zheng X et al. Odontogenic tumours: a retrospective study of 1642 cases in a Chinise population. Int. J. Oral Maxillofac Surg 2007; 36:20-25

Ahire MS, Tupkari JV, Chettiankandyb TJ, Thakur A, Agrawal RR. Odontogenic tumors: A 35-year retrospective study of 250 cases in an Indian CASE REPORT < 623(Maharashtra) teaching institute. Indian J Cancer. 2018; 55: 265-72

Regezi: Oral Pathology: Clinical Pathologic Correlations, 5th ed. An Imprint of Elsevier. WB Saunders, 2008: 745

Kim SA, Ahn SG, Kim SG, Park JC, Lee SH, Kim J, et al. Investigation of the beta-catenin gene in a case of Dentinogenic ghost cell tumour. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 103: 97-101

Yukimori A, Oikawa Y, Morita K, Nguyen CTK, Harada H, Yamaguchi S. Genetic basis of calcifying cystic odontogenic tumors. PLOS One. 2017; 12: e0180224.

Barnes L, Eveson JW, Reichart P, Sidransky D. World Health Organization Classification of Tumours. Pathology and Genetics of Head and

Neck Tumours. Lyon: IARC Press, 2005: 314.

Juneja M, George J. Dentinogenic ghost cell tumor: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 107: e17-22.

Praetorius F. Dentinogenic ghost cell tumour. In: Barnes L. editor. Surgical Pathology of the Head and Neck, Third Edition. CRC Press, 2009:1272-5.

Agrawal Y, Naidu GS, Makkad RS, Nagi R, Jain S, Gadewar DR et al. Dentinogenic ghost cell tumour – a rare case report with review of literature. Quant Imaging Med Surg 2017;7(5):598-604

Patankar SR, Khetan P, Choudhari SK, Suryavanshi H. Dentinogenic ghost cell tumour: A case report. World J Clin Oncol. 2019; 10(4): 192-200

Bafna SS, Joy T, Tupkari JV, Landge JS. Dentinogenic ghost cell tumor. J Oral Maxillofac Pathol. 2016; 20: 163

Reddy V, Wadhwan V, Singh R, Bansal V. Dentinogenic ghost cell tumour: Case report of a rare central variant and literature review. J Oral

Maxillofac Pathol. 2022; 26(1): 568-572

Garcia BG, Ruiz Masera JJ, Zafra Camacho FM, Gutierrez CC. Intraosseous dentinogenic ghost cell tumor: Case report and treatment review. Rev Esp Cir Oral Maxillofac. 2015; 37: 243-6.

Salgado I, Vilares M, Nogueira R, Rito M, Rosa F. Dentinogenic ghost cell tumour – Case report of a rare entity. International Journal of Surgery Case Reports. 2021; 81:105651

Konstantakis D, Kosyfaki P, Ebhardt H, Schmelzeisen R, Voss PJ. Intraosseous dentinogenic ghost cell tumor: A clinical report

and literature update. J Craniomaxillofac Surg. 2014;42:e305-11

Gupta S, Signh S, Anjum R, Sharma R, Dentinogenic ghost cell tumor of the maxilla: A case report and review of literature. J Oral Maxillofac pathol. 2019; 23 (3): 478.

Praetorius F, Hjørting-Hansen E, Gorlin RJ, Vickers RA. Calcifying odontogenic cyst. Range, variations and neoplastic potential. Acta Odontol Scand. 1981; 39: 227-40.

Sonawane K, Singaraju M, Gupta I, Singaraju S. Histopathologic diversity of Gorlin’s cyst: a study of four cases and review of literature. J Contemp Dent Pract 2011; 12: 392-397

Singhaniya SB, Barpande SR, Bhavthankar JD. Dentinogenic ghost cell tumor. J Oral Maxillofac Pathol. 2009; 13: 97-100

Kasahara K, Iizuka T, Kobayashi I, Totsuka Y, Kohgo T. A recurrent case of odontogenic ghost cell tumour of the mandible. Int J Oral Maxillofac Surg. 2002; 31: 684-7.

Sun G, Huang X, Hu Q, Yang X, Tang E. The diagnosis and treatment of Dentinogenic ghost cell tumor. Int J Oral Maxillofac Surg. 2009; 38:


de Arruda JAA, Monteiro JLGC, Abreu LG, de Oliveira Silva LV, Schuch LF, de Noronha MS, Callou G, Moreno A, Mesquita RA. Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review. J Oral Pathol Med. 2018; 47: 721-730




How to Cite

Lamola, M., Masilela, M., & Adedoja, T. (2022). Dentinogenic Ghost Cell Tumour, a rare case of an African young female patient: Review of literature and report of a case. South African Dental Journal, 77(10), 620–624.