Phenotypes and Clinical Genotypes of Bruxism Patients: A Systematic Review


  • RB Velasquez Department Prosthesis School of Dentistry, Universidad de Las Americas (UDLA) , Av. Colón y 6. Diciembre CP 170523, + 593023981000 ext 3060,Quito, Ecuador;
  • RA Zambrano Doctor in Dentistry Oral Rehabilitation Speciality, School of Dentistry, Universidad de las Americas (UDLA) , Av. Colón y 6. Diciembre CP 170523, + 593023981000 ext 3060, Quito, Ecuado
  • GA Ulloa Doctor in Dentistry Oral Rehabilitation Speciality , School of Dentistry, Universidad de las Americas (UDLA) , Av. Colón y 6. Diciembre CP 170523, + 593023981000 ext 3060, Quito, Ecuador
  • AA Sierra Doctor in Dentistry Oral Rehabilitation Speciality , School of Dentistry, Universidad de las Americas (UDLA) , Av. Colón y 6. Diciembre CP 170523, + 593023981000 ext 3060, Quito, Ecuador
  • TM Rodriguez Dentistry Resident, Faculty of Dentistry. University of Las Americas. UDLA. Campus Colón. +593958916317 CP 170523 Quito-Ecuador
  • LB Chauca Periodontics and Implantology Oral Research. College Dentistry. Universidad de Guayaquil, Ecuador.
  • MA Serrano Departamento de Investigación de Prótesis Dental. Facultad de Odontología. Universidad de Las Américas. UDLA. Campus Colón. +5930239981000 ext.3060. CP 170523 Quito-Ecuador



bruxism, temporomandibular joint disorders, phenotype, genotype, methylation.


Background. Bruxism is a phenomenon where psychological and exogenous biological factors act in greater percentage.
Several genetic polymorphisms have been described in GABAA receptors, and some have been associated with
motor limitations, such as the rs1805057 polymorphism of the GABRB1 gene (GABAA), which found a haplotype
associated with a lower limitation in movement in acute pain processes. The aim to identify the clinical phenotypes in
bruxism patients. Eligibility criteria were as follows: observational studies, case control studies, odds ratios, bruxism, patients, and a keyword search that included [[bruxism]], OR [[temporomandibular joint disorders]] OR [[sleep bruxism]], OR [[awake bruxism]],
OR [[polymorphism]] or [[GABAA]], or [[serotonin]] , using the Boolean operators AND, OR and NOT. Were included 210 identified records in databases; 50 records from other sources; 117 records were deleted after determining they were duplicates; 42 studies were
included in qualitative synthesis ; finally, who met inclusion requirements 5 studies were included in synthesis. The comparison of global DNA methylation profiles in patients with bruxism shows a possible genetic influence on their etiology, indicating that patients with HTR2A rs2770304 alleles are at increased risk. the HTR2A rs2770304 allele leads to an increased risk of bruxism.


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Author Biography

MA Serrano, Departamento de Investigación de Prótesis Dental. Facultad de Odontología. Universidad de Las Américas. UDLA. Campus Colón. +5930239981000 ext.3060. CP 170523 Quito-Ecuador


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How to Cite

Velasquez, R., Zambrano, R., Ulloa, G., Sierra, A., Rodriguez, T., Chauca, L., & Serrano, M. (2023). Phenotypes and Clinical Genotypes of Bruxism Patients: A Systematic Review. South African Dental Journal, 78(01), 56–61.