Neoplastic tissue transfiguration in vivo by recombinant human transforming growth factor-β3
DOI:
https://doi.org/10.17159/sadj.v78i02.16188Keywords:
Human transforming growth factor-β3 , human squamous cell carcinoma, tissue transfiguration, de-differentiation, neoplastic transformation.Abstract
Human oral squamous cell carcinomas (hSCCs) are the most common head and neck cancers now presenting with more aggressive biological and clinical features due to smoking and alcohol together with widespread viremia. Transforming growth factor-β (TGF-β) proteins are powerful morphogens that induce rapid and substantial induction of endochondral bone formation but in primates only.
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