Neoplastic tissue transfiguration in vivo by recombinant human transforming growth factor-β3
DOI:
https://doi.org/10.17159/sadj.v78i02.16188Keywords:
Human transforming growth factor-β3 , human squamous cell carcinoma, tissue transfiguration, de-differentiation, neoplastic transformation.Abstract
Human oral squamous cell carcinomas (hSCCs) are the most common head and neck cancers now presenting with more aggressive biological and clinical features due to smoking and alcohol together with widespread viremia. Transforming growth factor-β (TGF-β) proteins are powerful morphogens that induce rapid and substantial induction of endochondral bone formation but in primates only.
Downloads
References
Weinberg RA. Coming full circle – From endless complexity to simplicity and back again. Cell 2014;157:267-271. DOI: https://doi.org/10.1016/j.cell.2014.03.004
Garrana RM, Shangase SL, Mohangi GU. Oral squamous cell carcinoma, a growing problem. SADJ. 2018;73(10):491-496.
Irfan M, Delgado RZR, Frias-Lopez J. The oral microbiome and cancer. Front Immunol. 2020;11:5911088.https://doi/ org/doi:103389/fimmu.2020.591088 DOI: https://doi.org/10.3389/fimmu.2020.591088
Chen S-H, Hsiao S-Y, Chang K-Y, Chang J-Y. New insights into oral squamous cell carcinoma: From clinical aspects to molecular tumorigenesis. Int J Mol Sci. 2021;22, 2252. https://doi.org/doi:10.3390/ijms22052252 DOI: https://doi.org/10.3390/ijms22052252
Sasahira T, Kirita T. Hallmarks of cancer-related newly prognostic factors of oral squamous cell carcimoma. Int J Mol Sci. 2018;19,2413; https://doi.org/doi:10.3390/ijms19082413 DOI: https://doi.org/10.3390/ijms19082413
Ripamonti U, Ramoshebi LN, Teare J, Renton L, Ferretti C. The induction of endochondral bone formation by transforming growth factor-β3
: Experimental studies in the non-human primate Papio ursinus. J Cell Mol Med. 2008;12(3):1029-1048.
doi:10.1111/J.1582-4934.2008.00126.x. DOI: https://doi.org/10.1111/j.1582-4934.2008.00126.x
Ripamonti U. Rapid induction of bone formation by the transforming growth factor-β3isoform. In: Induction of bone formation in primates. In: Ripamonti U, editor. The Transforming growth factor-beta3. Ripamonti U (Ed), CRC Press Boca Raton, USA,
p. 47-74.
Ripamonti U, Dix-Peek T, Parak R, Milner B, Duarte R. Profiling bone morphogenetic proteins and transforming growth factor-βs by hTGF-β3 pre-treated coral-derived macroporous bioreactors: the power of one. Biomaterials 2015;35:90-102. DOI: https://doi.org/10.1016/j.biomaterials.2015.01.058
Kengkarn S, Petmitr S, Boonyueni U, Reamtong O, Poomsawat S, Sanguansin S. Identification of novel candidate biomarkers for oral squamous cell carcinoma based on whole gene expression profiling. Path & Oncol Res. 2020;26:2315–2325. DOI: https://doi.org/10.1007/s12253-020-00828-w
Arias J-I, Aller M-A, Prieto I, Arias A, de Julian Z, Yang H, Arias J.The amazing power of cancer cells to recapitulate extraembryonic functions: The cuckoo’s tricks. J Oncol. 2012, doi:10.1155/2012/521284. DOI: https://doi.org/10.1155/2012/521284
Tang B, Yoo N, Vu M, Arias A, Namura M, Nam J-S, Ooshima A, Du Z, Desprez P-Y, Anver MR, Michalowska AM, Shih J, Parks WT, Wakefield LM. TGF-β can suppress tumorigenesis through effects on the putative cancer stem or early progenitor
cell and committed progeny in a breast cancer xenograft model. Cancer Res. 2007;67(18):8643-8652. DOI: https://doi.org/10.1158/0008-5472.CAN-07-0982
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
.png){kind=spacer}