Oral and Oropharyngeal HPV prevalence in South Africa A systematic review and meta-analysis
DOI:
https://doi.org/10.17159/2519-0105/2021/v76no10a8Keywords:
HPV prevalence, oropharynx, oral, HPV, human papillomavirusAbstract
Prevalence data for HPV infection in the head and neck in Southern African populations is lacking. In addition to cervical cancer, this sexually transmitted oncogenic virus is responsible for a subset of head and neck cancer and is transmitted via oral sexual routes, and through other forms of intimate contact between anatomical sites lined by mucosa. This systematic review and meta-analyses
aimed to synthesize data for the prevalence of head and neck HPV infection in South Africa. Original research papers from South Africa reporting on the prevalence of HPV in the head and neck was systematically reviewed using PubMed, Ovid Medline, Embase and the Cochrane Library. A meta-analysis on the prevalence data wasconducted for 16 papers that met the inclusion criteria.
Downloads
References
IARC. Monographs on the evaluation of carcinogenic risks to humans, volume 100. A review of carcinogen-Part B: biological agents. Lyon:
International Agency for Research on Cancer, 2011.
Wood NH, Makua KS, Lebelo RL, Redzic N, Benoy I, Vanderveken OM, et al. Human papillomavirus prevalence in oral and oropharyngeal
rinse and gargle specimens of dental patients and of an HIV-positive cohort from Pretoria, South Africa. Adv in Virol. 2020; ID 2395219; doi. org/10.1155/2020/2395219
Syrjänen S. Oral manifestations of human papillomavirus infections. Eur J Oral Sci. 2018; 126(S1):49–66.
Syrjänen KJ. Human papillomavirus (HPV) infections and their associations with squamous www.sada.co.za / SADJ Vol. 76 No.10
REVIEW < 637 cell neoplasia. Arch Geschwulstforsch 1987; 57:417–444.
Syrjänen S, Lodi G, von Bültzingslöwen I, Aliko A, Arduino P, Campisi G, et al. Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis 2011; 17(S1):58–72.
Grce M, Mravak-Stipetic M. Human papillomavirus-associated diseases. Clin Dermatol 2014; 32:253–258.
Chaturvedi AK, Anderson WF, Lortet-Tieulent J, Curado MP, Ferlay J, Franceschi S, et al. Worldwide trends in incidence rates for oral cavity
and oropharyngeal cancers. J Clin Oncol 2013; 34:4550-4554.
Leemans CR, Snijders PJ, Brakenhoff RH. The molecular landscape of head and neck cancer. Nature Rev 2018; 18:269-282.
Tam S, Fu S, Xu L, Krause KJ, Lairson DR, Miao H, et al. The epidemiology of oral human papillomavirus infection in healthy populations: A systematic review and meta-analysis. Oral Oncol 2018; 82:91-99.
Yete S, D’Souza W, Saranath D. High-risk Human papillomavirus in oral cancer: Clinical implications. Oncology 2018; 94:133-141.
Komloš KF, Kocjan BJ, Košorok P, Luzar B, Meglič L, Potočnik M, et al. Tumor-specific and gender-specific pre-vaccination distribution of
human papillomavirus types 6 and 11 in anogenital warts and laryngeal papillomas: A study on 574 tissue specimens. J Med Virol 2012; 84:1233-1241.
Danielewski JA, Garland SM, McCloskey J, Hillman RJ, Tabrizi SN. Human papillomavirus type 6 and 11 genetic variants found in 71 oral and anogenital epithelial samples from Australia. PLOS ONE 2013; 8:e63892; doi.org/10.1371/journal.pone.0063892
Mehanna H, Beech T, Nicholson T, El-Hariry I, McConkey C, Paleri V, et al. Prevalence of Human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer – systematic review and meta-analysis of trends by time and region. Head & Neck 2013; 35:747-755.
Sanders AE, Slade GD, Patton LL. National prevalence of oral HPV infection and related risk factors in the U.S. adult population. Oral Dis 2012; 18:430–441.
Prabhat MP, Lakshmi CR, Madhavi NS, Bhavana SM, Sarat G, Ramamohan K. Multifocal epithelial hyperplasia of oral cavity expressing HPV 16 gene: a rare entity. Case Reports in Dent 2013; doi.org/10.1155/2013/871306
Boy S, Janse van Rensburg E, Engelbrecht S, Dreyer L, Van Heerden M, Van Heerden W. HPV detection in primary intra-oral squamous cell
carcinomas – commensal, aetiological agent or contamination? J Oral Pathol Med 2006; 35:86–90.
Fatahzadeh M, Schlecht NF, Chen Z, Bottalico D, McKinney S, Ostoloza J, et al. Oral human papillomavirus detection in older adults who have human immunodeficiency virus infection. Oral Surg Oral Med Oral Pathol Oral Radiol 2013; 115:505-514.
Paquette C, Evans MF, Meer SS, Rajendran V, Adamson CS, Cooper K. Evidence that alpha-9 human papillomavirus infections are a major etiologic factor for oropharyngeal carcinoma in black South Africans. Head and Neck Pathol 2013; 7:361-372.
Gaester K, Fonseca LA, Luiz O, Assone T, Fontes AS, Costa F, et al. Human papillomavirus infection in oral fluids of HIV-1-positive men: prevalence and risk factors. Sci Rep 2014; 4:6592.
De Martel C, Ferlay J, Francheschi S, Vignat J, Bray F, Forman D, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol 2012; 13:607–15.
Bruni L, Albero G, Serrano B, Mena M, Gómez D, Muñoz J, et al. ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre).
Human Papillomavirus and Related Diseases in the World. Summary Report, 17 June 2019. https://www.hpvcentre.ne t/statistics/reports/XWX.pdf, (accessed 3 August 2020).
Mbulawa ZZA, Johnson LF, Marais DJ, Coetzee D, Williamson A. Risk factors for oral human papillomavirus in heterosexual couples in an African setting. J Infect 2014; 68:185-189.
Chikandiwa A, Pisa PT, Chersich MF, Muller EE, Mayaud P, Delaney-Moretlwe S. Oropharyngeal
HPV infection: prevalence and sampling methods among HIV-infected men in South Africa. Int J STD & AIDS 2018; 29:776-780.
Muller EE, Rebe K, Chirwa TF, Struthers H, McIntyre J, Lewis DA. The prevalence of human papillomavirus infections and associated risk factors in men-who-have-sex-with-men in Cape Town, South Africa. BMC Infect Dis 2016; 16:440.
Davidson CL, Richter KL, van der Linde M, Coetsee J, Boy SC. Prevalence of oral and oropharyngeal human papillomavirus in a sample of South African men: A pilot study. SAMJ 2014; 104:358–361.
Richter KL, Janse van Rensburg E, van Heerden WFP, Boy SC. Human papilloma virus types in the oral and cervical mucosa of HIV-positive South African women prior to antiretroviral therapy. J Oral Path Med 2008; 37:555-559.
Vogt SL, Gravitt PE, Martinson NA, Hoffman J, D’Souza G. Concordant oral-genital HPV infection in South Africa couples: evidence for transmission. Frontier Oncol: Cancer Epidem Prev 2013; 3:1-7.
Van Rensburg EJ, van Heerden WF, Venter EH, Raubenheimer EJ. Detection of human papillomavirus DNA with in situ hybridisation in oral squamous carcinoma in a rural black population. S Afr Med J 1995; 85:894-896.
Van Rensburg EJ, Engelbrecht S, Van Heerden WF, Raubenheimer EJ, Schoub BD. Human papillomavirus DNA in oral squamous cell carcinomas from an African population sample. Anticancer Res 1996; 16:969-973.
Mistry HB. Dissertation: Prevalence of oral and oro-pharyngeal Human papillomavirus infection in a selected cohort of men from a rural/semi-rural area in Gauteng, South Africa. Sefako Makgatho Health Sciences University, Pretoria, South Africa, 2011.
https://www.smu.ac.za/library/
Marais DJ, Passmore DS, Denny L, Sampson C, Allan BR, Williamson A. Cervical and oral Human papillomavirus types in HIV-1 positive and negative www.sada.co.za / SADJ Vol. 76 No.10 638 > REVIEWwomen with cervical disease in South Africa. J Med Virol 2008; 80:953–959.
Marais DJ, Sampson C, Jeftha A, Dhaya D, Passmore J, Denny L, et al. More men than women make mucosal IgA antibodies to Human
papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population. BMC Infect Dis 2006;
:95.
Sekee TR, Burt FJ, Goedhals D, Goedhals J, Munsamy Y, Seedat RY. Human papillomavirus in head and neck squamous cell carcinomas in a
South African cohort. Papillomavirus Res 2018; 6:58-62.
Bulane A, Goedhals D, Seedat RY, Goedhals J, Burt F. Human papillomavirus DNA in head and neck squamous cell carcinomas in the Free State, South Africa. J Med Virol 2020; 92:227-233.
Kreimer AR, Bhatia RK, Messeguer AL, González, P, Herrero, R, Giuliano, AR. Oral Human papillomavirus in healthy individuals: A systematic review of the literature. Sex Transm Dis 2010; 37:386-391.
Gillison ML, Broutian T, Pickard RK, Tong Z, Xiao W, Kahle L, et al. Prevalence of oral HPV infection in the United States, 2009-2010. JAMA 2012; 307:693-703.
Adamopoulou M, Viaraktaris E, Nkenke E, Avgoustidis D, Karakitsos P, Sioulas V, et al. Prevelance of human papillomavirus in saliva and
cervix of sexually active women. Gynecol Oncol 2013; 129:395-400.
Pinheiro RS, de Franca TR, Rocha B, Ferreira DC, Ribeiro CMB, Cavalcanti SMB, et al. Human papillomavirus coinfection in the oral cavity
of HIV-infected children. J Clin Pathol 2011; 64:1083-1087.
D’Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356:1944 –1956.
Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2008; 45:309-316.
Dayyani F, Etzel CJ, Liu M, Ho C, Lippman SM, Tsao AS. Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC). Head Neck Oncol 2010; 2:15.
Mravak-Stipetić M, Sabol I, Kranjčić J, Knežević M, Grce M. Human papillomavirus in the lesions of the oral mucosa according to topography. PLoS ONE 2013; 8:e69736.
Matos, LL, Miranda GA, Cernea CR. Prevalence of oral and oropharyngeal human papillomavirus infection in Brazilian population studies: a systematic review. Brazil J Otorhinolaryngol 2015; 81:554-567.
D'souza G, Carey TE, William WN Jr, Nguyen ML, Ko EC, Ridell J IV, et al. Epidemiology of head and neck squamous cell cancer among HIV-infected patients. J Acquir Immune Defic Syndr 2014; 65:603-610.
Beachler DC, D’Souza G. Oral HPV infection and head and neck cancers in HIV-infected individuals.Curr Opin Oncol 2013; 25;503-510.
Jayaprakash V, Reid M, Hatton E, Merzianu M, Rigual N, Marshall J, et al. Human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: a meta-analysis, 1985-2010. Oral Oncol 2011; 47:1048-1054.
Trzcinska A, Zhang W, Gitman M, Westra WH. The Prevalence, Anatomic Distribution and Significance of HPV Genotypes in Head and Neck Squamous Papillomas as Detected by Real-Time PCR and Sanger Sequencing. Head and Neck Pathol 2020; 14:428-434.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
.png){kind=spacer}