A 30-year Review of Ameloblastoma: A tertiary hospital-based study
Keywords:Ameloblastoma, Black, Acanthomatous, Expansile
The clinical, histological and radiographic presentation of ameloblastoma is well described in literature. This odontogenic tumour commonly affect the mandible, locally aggressive and destructive resulting in disfigurement. It arises from dental tissues at various phases of tooth development. They are generally asymptomatic, slow growing, locally invasive and rarely malignant with a high recurrence rate.
Retrospective review of ameloblastoma cases spanned between 1991 and 2022.
Data analysis was based on 185 histologically confirmed cases. Appropriate descriptive and inferential statistics were undertaken on, age, gender, clinical, radiographic and histological characteristics.
The average age was 28.81 (14.53), ranging between 3-75 years. The overall male to female ratio stood at 1.18:1. Ameloblastomas were prevalent in the mandible 174(94.1%), diagnosed as conventional variant 155(83.7%) and acanthomatous subtype. Radiographically, the lesions appeared as multilocular 97(55.4%), radiolucent 100(54.1%) and expansile 129(67.7%). The average size of the lesions was 77.43 ± 33.83 mm, with a range of 184 mm.
Our results validate the hypothesis that ameloblastoma is highly prevalent among black Africans of younger age. The radiographic, clinical, and histological characteristics of ameloblastoma in our population are comparable to the vast literature.
Angadi PV. Head and neck: odontogenic tumor: ameloblastoma. Atlas of Genetics and Cytogenetics in Oncology and Haematology. 2011.
Masthan KM, Anitha N, Krupaa J et al. Ameloblastoma. J Pharm Bioallied Sci. 2015;7: S167-170. https://doi.org/10.4103/0975-7406.155891
Santosh ABR, Ogle OE. Odontogenic Tumors. Dent Clin North Am. 2020; 64: 121-138. https://doi.org/10.1016/j.cden.2019.08.008
Kreppel M, Zöller J. Ameloblastoma—Clinical, radiological, and therapeutic findings. Oral diseases. 2018;24: 63-66
Effiom O, Ogundana O, Akinshipo, A et al. Ameloblastoma: current etiopathological concepts and management. Oral diseases. 2018; 24: 307-316
Milman T, Ying GS, Pan W et al. Ameloblastoma: 25 Year Experience at a Single Institution. Head Neck Pathol. 2016; 10: 513-520.
Vickers RA, Gorlin RJ. Ameloblastoma: Delineation of early histopathologic features of neoplasia. Cancer. 1970;26(3):699-710. https://doi.org/10.1002/1097-0142(197009)26:3
Cadavid, AMH, Araujo JP, Coutinho-Camillo CM et al. Ameloblastomas: current aspects of the new WHO classification in an analysis of 136 cases. Surg Exp Pathol. 2019; 2:17. https://doi.org/10.1186/s42047-019-0041-z
Tatapudi R, Samad SA, Reddy RS et al. Prevalence of ameloblastoma: A three-year retrospective study. Journal of Indian Academy of Oral Medicine and Radiology. 2014; 26:2 145-51
Hertog D, Bloemena E, Aartman IHA et al. Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience. Med Oral Patol Oral Cir Bucal. 2012;17: e76-e82.https://doi.org/10.4317/medoral.18006
Ranchod S, Titinchi F, Behardien N et al. Ameloblastoma of the mandible: analysis of radiographic and histopathological features. Journal of Oral Medicine and Oral Surgery. 2020;27. https://doi.org/10.1051/mbcb/2020051
Tatapudi R, Samad SA, Reddy RS et al. Prevalence of ameloblastoma: A three-year retrospective study. Journal of Indian Academy of Oral Medicine
Kim S. G. & Jang, H. S. Ameloblastoma: a clinical, radiographic, and histopathologic analysis of 71 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91, 649-653, doi:10.1067/moe.2001.114160 (2001).
Hendra FN, Van Cann EM, Helder MN et al. Global incidence and profile of ameloblastoma: A systematic review and meta-analysis. Oral diseases. 2020;26(1): 12–21. https://doi.org/10.1111/odi.13031
Giraddi GB, Arora K, Saifi AM. Ameloblastoma: A retrospective analysis of 31 cases. J Oral Biol Craniofac Res. 2017; 7: 206-211.https:// doi.org/10.1016/j.jobcr.2017.08.007
Laborde A, Nicot R, Wojcik T et al.Ameloblastoma of the jaws: Management and recurrence rate. European annals of otorhinolaryngology, head and neck diseases. 207; 134: 7-11
Arotiba GT, Hille J, Guthua SW al. Ameloblastoma in Black Africans the Need for Multi-National Collaborative Research. JSM Dent Surg.2017; 2(2): 1014-9.
Ladeinde AL, Ogunlewe MO, Bamgbose BO et al. Ameloblastoma: analysis of 207 cases in a Nigerian teaching hospital. Quintessence international. 2006; 37(1): 69–74.
Reichart P, Philipsen H, Sonner S. Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol. 1995; 31B: 86-99
Bwambale, P, Yahaya JJ, Owor G et al. Histopathological patterns and biological characteristics of ameloblastoma: A retrospective cross-sectional study. Journal of Taibah University Medical Sciences. 2022; 17: 96-104.https://doi.org/10.1016/j.jtumed.2021.09.007
Chawla R, Ramalingam K, Sarkar A et al. Ninety-one cases of ameloblastoma in an Indian population: A comprehensive review. J Nat Sci Biol Med.2013; 4: 310-315. https://doi.org/:10.4103/0976-9668.116984
Ogunsalu C, Daisley H, Henry K., et al. A new radiological classification for ameloblastoma based on analysis of 19 cases. West Indian Med J.2006; 55(6): 434-439. https://doi.org/10.1590/s0043-31442006000600013
Struthers P, Shear M. Root resorption by ameloblastomas and cysts of the jaws. International Journal of Oral Surgery. 1976; 5: 128-132.https://doi.org/10.1016/S0300-9785(76)80061-0
Martins GG, Oliveira IA, Consolaro A. The mechanism: how dental resorptions occur in ameloblastoma. Dental Press J Orthod. 2019; 24:21-32. https://doi.org/10.1590/2177-6709.24.4.021-032.oin.
How to Cite
Copyright (c) 2023 Alan, Lesley, Pagollang
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.