Prevalence of oral mucosal and periodontal disease amongst patients receiving dialysis
DOI:
https://doi.org/10.17159/2519-0105/2022/v77no9a1Keywords:
Chronic kidney diseaseAbstract
End-stage renal disease (ESRD) requires renal replacement therapy (RRT), namely a renal transplant or renal dialysis or both. Dialysis corrects the electrolyte imbalance and reduces circulating urea and creatinine levels. ESRD patients may present with oral complications and disease due to impaired renal functions, associated comorbidities, or the pharmacological management thereof.
To determine the prevalence of periodontal- and oral mucosal disease in ESRD patients undergoing dialysis. Recommendations will be made regarding dental treatment needs and dental management. Cross-sectional study. Fifty-three ESRD patients were evaluated for mucosal lesions and periodontal disease. Patient's age, race, gender, comorbidities, dialysis duration and medicationwere recorded. Treatment urgency was determined, and patients referred accordingly for appropriate dental treatment. Mean age of patients was 42,9 ±10,4 years with a median time on dialysis of 30 months. Majority of patients were hypertensive (94.34%). No oral mucosal lesions was found. PSR score of 3 was mostly found (36.58%). Sixty-two percent of patients had a moderate treatment urgency.
A relationship between chronic kidney disease and periodontitis exists. ESRD patients should thus be enrolled into a periodontal screening and treatment program and all dental treatmen
Downloads
References
Jassal SV. Clinical presentation of renal failure in the aged: chronic renal failure. Clinics in geriatric medicine. 2009;25(3):359-372.
Costantinides F, Castronovo G, Vettori E, et al. Dental Care for Patients with End-Stage Renal Disease and Undergoing Hemodialysis. International journal of dentistry. 2018;2018:9610892.
Hassan A, Mary B, Faissal S. The integrated care pathway of nephrology and dental teams to manage complex renal and postkidney transplant patients in dentistry: A holistic approach. Saudi Journal of Kidney Diseases and Transplantation. 2018;29(4):766-774.
Yuan Q, Xiong QC, Gupta M, et al. Dental implant treatment for renal failure patients on dialysis: a clinical guideline. International journal of oral science. 2017;9(3):125-132.
Schmalz G, Kauffels A, Otto K, et al. Oral behavior, dental, periodontal and microbiological findings in patients undergoing hemodialysis and after kidney transplantation. BMC Oral Health. 2016;16:72.
Ziebolz D, Fischer P, Hornecker E, Mausberg RF. Oral health of hemodialysis patients: A crosssectional study at two German dialysis centers. Hemodialysis International. 2012;16(1):69-75.
Duran I, Erdemir EO. Periodontal treatment needs of patients with renal disease receiving haemodialysis. International Dental Journal.
;54(5):274-278.
Mallick NP, Gokal R. Haemodialysis. The Lancet. 1999;353(9154):737-742.
Sturgill J, Howell S, Perry MM, Kothari H. Protocols for treating patients with end-stage renal disease: a survey of undergraduate dental programs. Special Care in Dentistry. 2016;36(6):321-324.
Landry RG, Jean M. Periodontal Screening and Recording (PSR) Index: precursors, utility and limitations in a clinical setting. International Dental Journal. 2002;52(1):35-40.
Beltrán-Aguilar ED, Eke PI, Thornton-Evans G, Petersen PE. Recording and surveillance systems for periodontal diseases. Periodontology 2000. 2012;60(1):40-53.
Dhingra K, Vandana KL. Indices for measuring periodontitis: a literature review. International Dental Journal. 2011;61(2):76-84.
Van der Velden U. Diagnosis of periodontitis. Journal of clinical periodontology. 2000;27(12):960-961.
Papapanou PN, Sanz M, Buduneli N, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of Clinical Periodontology. 2018;45(S20):S162-S170.
Proctor R, Kumar N, Stein A, Moles D, Porter S. =Oral and dental aspects of chronic renal failure. Journal of dental research. 2005;84(3):199-208.
de la Rosa García E, Mondragón Padilla A, Aranda Romo S, Bustamante Ramírez MA. Oral mucosa symptoms, signs and lesions, in end
stage renal disease and non-end stage renal disease diabetic patients. Medicina Oral, Patología Oral y Cirugía Bucal (Internet). 2006. http://
scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1698-69462006000600003.
Klassen JT, Krasko BM. The Dental Health Status of Dialysis Patients. J Can Dent Assoc. 2002;68(1):34-38.
Camacho-Alonso F, Cánovas-García C, MartínezOrtiz C, et al. Oral status, quality of life, and anxiety and depression in hemodialysis patients and the effect of the duration of treatment by dialysis on these variables. Odontology : Official Journal of the Society of the Nippon Dental University. 2018;106(2):194-201.
Tadakamadla J, Kumar S, Mamatha GP. Comparative evaluation of oral health status of chronic kidney disease (CKD) patients in various
stages and healthy controls. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of
Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. 2014;34(3):122-126.
Olivas-Escárcega V, Rui-Rodríguez Mdel S, Fonseca-Leal Mdel P, et al. Prevalence of oral candidiasis in chronic renal failure and renal
transplant pediatric patients. The Journal of clinical pediatric dentistry. 2008;32(4):313-317.
Preshaw PM, Bissett SM. Periodontitis and diabetes. British dental journal. 2019;227(7):577-532 > RESEARCH www.sada.co.za / SADJ Vol. 77 No. 9584.
Scannapieco FA, Cantos A. Oral inflammation and infection, and chronic medical diseases: implications for the elderly. Periodontology 2000. 2016;72(1):153-175.
Palanca A, Castelblanco E, Perpiñán H, et al. Prevalence and progression of subclinical atherosclerosis in patients with chronic
kidney disease and diabetes. Atherosclerosis. 2018;276:50-57.
Tonetti MS, Van Dyke TE, Working group 1 of the joint EFPAAPw. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. Journal of clinical periodontology. 2013;40(Suppl 14):24-29.
Jair CLo, Luiz Alcino MG, Airton VLS, Alessandra ATC, Willian B, Stephen RP. Uremic stomatitis in chronic renal failure. Clinics. 2005;60(3):259-262.
Liao CY, Wu CC, Chu PL. Uremic stomatitis. QJM: An International Journal of Medicine. 2017;110(4):247-248.
Pugh D, Gallacher PJ, Dhaun N. Management of Hypertension in Chronic Kidney Disease. Drugs. 2020;79(4):365-379.
Seedat YK, Rayner BL, Veriava Y, Hypertension guideline working g. South African hypertension practice guideline 2014. Cardiovascular journal of Africa. 2014;25(6):288-294.
Seymour RA, Thomason JM, Ellis JS. The pathogenesis of drug-induced gingival overgrowth. Journal of Clinical Periodontology. 1996;23(3):165-175.
Ellis JS, Seymour RA, Thomason JM, Monkman SC, Idle JR. Gingival sequestration of amlodipine and amlodipine-induced gingival overgrowth. Lancet (London, England). 1993;341(8852):1102-1103.
Ellis JS, Seymour RA, Monkman SC, Idle JR. Gingival sequestration of nifedipine in nifedipineinduced gingival overgrowth. Lancet (London,
England). 1992;339(8806):1382-1383.
Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM. Prevalence of Gingival Overgrowth Induced by Calcium Channel
Blockers: A Community-Based Study. Journal of Periodontology. 1999;70(1):63-67.
Ishida H, Kondoh T, Kataoka M, et al. Factors Influencing Nifedipine-Induced Gingival Overgrowth in Rats. Journal of Periodontology. 1995;66(5):345-350.
Villa A, Wolff A, Aframian D, et al. World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis, and treatment. Clinical Oral Investigations. 2015;19(7):1563-1580.
Ramírez L, Sánchez I, Muñoz M, et al. Risk factors associated with xerostomia and reduced salivary flow in hypertensive patients. Oral diseases. 2021.
Yuan A, Woo SB. Adverse drug events in the oral cavity. Oral surgery, oral medicine, oral pathology and oral radiology. 2015;119(1):35-47.
Kragelund C, Hansen C, Reibel J, et al. Can the genotype or phenotype of two polymorphic drug metabolising cytochrome P450-enzymes identify oral lichenoid drug eruptions? Journal of Oral Pathology & Medicine. 2010;39(6):497-505.
Davidovich E, Davidovits M, Eidelman E, Schwarz Z, Bimstein E. Pathophysiology, therapy, and oral implications of renal failure in children and adolescents: an update. Pediatric dentistry. 2005;27(2):98-106.
Craig RG. Interactions between chronic renal disease and periodontal disease. Oral Diseases. 2008;14(1):1-7.
Cengiz MI, Sümer P, Cengiz S, Yavuz U. The effect of the duration of the dialysis in hemodialysis patients on dental and periodontal findings. Oral Diseases. 2009;15(5):336-341.
Bayraktar G, Kurtulus I, Duraduryan A, et al. Dental and periodontal findings in hemodialysis patients. Oral Diseases. 2007;13(4):393-397.
Bots CP, Poorterman JHG, Brand HS, et al. The oral health status of dentate patients with chronic renal failure undergoing dialysis therapy. Oral Diseases. 2006;12(2):176-180.
Gavaldá C, Bagán J, Scully C, Silvestre F, Milián M, Jiménez-Soriano Y. Renal Hemodialysis Patients: Oral, Salivary, Dental and Periodontal Findings in 105 Adult Cases. Oral Diseases. 1999;5(4):299-302.
Chikte U, Pontes CC, Karangwa I, et al. Periodontal Disease Status among Adults from South AfricaPrevalence and Effect of Smoking. International journal of environmental research and public health. 2019;16(19).
Craig RG, Yip JK, So MK, Boylan RJ, Socransky SS, Haffajee AD. Relationship of Destructive Periodontal Disease to the Acute-Phase Response. Journal of Periodontology. 2003;74(7):1007-1016.
Chambrone L, Foz AM, Guglielmetti MR, et al. Periodontitis and chronic kidney disease: a systematic review of the association of diseases
and the effect of periodontal treatment on estimated glomerular filtration rate. Journal of Clinical Periodontology. 2013;40(5):443-456.
de Oliveira C, Galgut, Watt R, Hamer M. Toothbrushing, inflammation, and risk of cardiovascular disease: results from Scottish
Health Survey. BMJ: British Medical Journal. 2010;340(7761):1400.
Van Dyke TE, Serhan CN. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. Journal of dental research. 2003;82(2):82-90.
Rodrigues VP, Libério SA, Lopes FF, et al. Periodontal status and serum biomarkers levels in haemodialysis patients. Journal of clinical
periodontology. 2014;41(9):862-868.
Yeun JY, Levine RA, Mantadilok V, Kaysen GA. C-Reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients.
Am J Kidney Dis. 2000;35(3):469-476.
Chen L-P, Chiang C-K, Peng Y-S, et al.Relationship Between Periodontal Disease and Mortality in Patients Treated With Maintenance
Hemodialysis. American Journal of Kidney Diseases. 2011;57(2):276-282.RESEARCH < 533
D’Aiuto F, Parkar M, Andreou G, et al. Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers. Journal of Dental Research. 2004;83(2):156-160.
D’Aiuto F, Nibali L, Parkar M, Suvan J, Tonetti MS. Short-term Effects of Intensive Periodontal Therapy on Serum Inflammatory Markers and Cholesterol. Journal of Dental Research. 2005;84(3):269-273.
Deschamps-Lenhardt S, Martin-Cabezas R, Hannedouche T, Huck O. Association between periodontitis and chronic kidney disease:
Systematic review and meta-analysis. Oral diseases. 2019;25(2):385-402.
Aronoff GR, Berns JS, Brier ME, et al. Drug prescribing in renal failure: Dosing guidelines for adults. American Journal of Kidney Diseases.
;34(1):203-204.
Tasdemir Z, Özsarı Tasdemir F, Gürgan C, Eroglu E, Gunturk I, kocyigit I. The effect of periodontal disease treatment in patients with continuous ambulatory peritoneal dialysis. International Urology and Nephrology. 2018;50(8):1519-1528.
Wang AY, Lai KN. Use of cardiac biomarkers in end-stage renal disease. Journal of the American Society of Nephrology : JASN. 2008;19(9):1643-1652.
Fregoneze AP, Ortega Ad, Brancher JA, et al. Clinical evaluation of dental treatment needs in chronic renal insufficiency patients. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. 2015;35(2):63-67.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
.png){kind=spacer}