MAXILLOFACIAL RADIOLOGY Nevoid Basal Cell Carcinoma Syndrome

Authors

  • Lené Merbold
  • Zarah Yakoob General Management (GIBS Pret), Department of Oral and Maxillofacial Pathology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, South Africa https://orcid.org/0000-0003-1966-5574

DOI:

https://doi.org/10.17159/sadj.v78i07.17071

Keywords:

distal, lesion

Abstract

An 18-year-old male patient presented at our dental clinic in 2009 for a dental assessment. A panoramic radiograph was taken to evaluate dental crowning (Figure 1). An incidental finding was noted in the right maxilla, presenting as a well-demarcated, round, unilocular, radiolucent lesion with a corticated rim extending from the right maxillary tuberosity area to distal of the 16 causing.
impaction of the 18. A biopsy was taken and diagnosed as an odontogenic keratocyst (OKC) that was subsequently enucleated. In 2021 the patient returned, and another panoramic radiograph (Figure 2) and a Waters view was taken where calcification of the falx cerebri was seen (Figure 3). On the panoramic radiograph an additional mandibular lesion was visible that presented as a well-demarcated, round, unilocular, radiolucent lesion with a corticated rim extending from distal of the 46 into the missing 47, 48 area. A CBCT was then.
taken to further analyse the lesions (Figure 4). A biopsy was taken in the right posterior mandible and diagnosed as an OKC. In 2023 the patient returned and a CBCT was taken. The right maxilla showed increased bone density adjacent to the enucleated lesion (Figure 5).

Downloads

Download data is not yet available.

References

Neville, BW, Damm, DD, Allen, CM, Chi, AC (2016). Oral and Maxillofacial Pathology. 4th Edition, WB Saunders, Elsevier, Missouri, 640-644

Lo Muzio, L (2008). Nevoid basal cell carcinoma syndrome (gorlin syndrome). Orphanet Journal of Rare Diseases, 3, 32-32. https://doi.org/10.1186/1750-1172-3-32 DOI: https://doi.org/10.1186/1750-1172-3-32

Manfredi, M, Vescovi, P, Bonanini, M, Porter, S (2004). Nevoid basal cell carcinoma syndrome: a review of the literature. International Journal of Oral & Maxillofacial Surgery, 33(2), 117-124. https://doi.org/10.1054/ijom.2003.0435 DOI: https://doi.org/10.1054/ijom.2003.0435

Ambele, MA, Robinson, L, van Heerden, MB, Pepper, MS, van Heerden, WFP (2023). Comparative Molecular Genetics of Odontogenic Keratocysts in Sporadic and Syndromic Patients. Modern pathology: an offi cial journal of the United States

and Canadian Academy of Pathology, Inc, 36(1), 100002 https://doi.org/10.1016/j.modpat.2022.100002 DOI: https://doi.org/10.1016/j.modpat.2022.100002

Bellei, B, Caputo, S, Carbone, A, Silipo, V, Papaccio, F, Picardo, M, Eibenschutz, L (2020). The role of dermal fibroblasts in nevoid basal cell carcinoma syndrome patients: an overview. International Journal of Molecular Sciences, 21(3). https://doi. DOI: https://doi.org/10.3390/ijms21030720

org/10.3390/ijms21030720

Ünsal, G, Cicciù, M, Ayman Ahmad Saleh, R, Riyadh Ali Hammamy, M, Amer Kadri, A, Kuran, B, Minervini, G (2023). Radiological evaluation of odontogenic keratocysts in patients with nevoid basal cell carcinoma syndrome: a review. The Saudi Dental

Journal. https://doi.org/10.1016/j.sdentj.2023.05.023 DOI: https://doi.org/10.1016/j.sdentj.2023.05.023

Downloads

Published

2023-08-31

How to Cite

MAXILLOFACIAL RADIOLOGY Nevoid Basal Cell Carcinoma Syndrome. (2023). South African Dental Journal, 78(07), 338-339. https://doi.org/10.17159/sadj.v78i07.17071