A Review of the role of Nuclear Medicine Imaging in Diagnostic Dentistry
DOI:
https://doi.org/10.17159/2519-0105/2021/v76no10a7Keywords:
Nuclear medicine, Dentistry, Head and neck, Positron emission tomography (PET), Single photon emission computed tomography (SPECT), Bone scintigraphy, Lymphoscintigraphy, Hybrid imaging.Abstract
The increasing scope of nuclear medicine imaging as a diagnostic utility is impressive. Plain film radiographs, computed tomography (CT) scans and magnetic resonance imaging (MRI) diagnostically provide high-quality images but provide little physiological information about disease processes. Nuclear medicine imaging modalities advantageously can characterise the early dynamic physiological changes in a diseased environment. Dental professionals working within the arena of integrated holistic health practices are likely to encounter patients having had procedures like conventional scintigraphy, single photon emission computed tomography (SPECT), hybrid SPECT/CT and positron emission tomography computed tomography (PET/CT). The aim of this review is to acquaint the oral health care professional with some commonly utilised nuclear medicine techniques, the principles upon which such modalities are based and their applications in the diagnosis of head and neck pathology to facilitate enhanced multidisciplinary patient management.
Downloads
References
Brenner AI, Koshy J, Morey J, Lin C, Dipoce J. The bone scan. Semin Nucl Med.2012. 299 42(1):11– 26.
Love C, Din AS, Tomas MB, Kalapparambath TP, Palestro CJ. Radionuclide Bone Imaging: An Illustrative Review. Radiographics. 2003;23(2):341–58.
Cook GJR. Imaging with radiolabelled bisphosphonates. Bone [Internet]. 2020; 137:115372.
Ferreira RI, de Almeida SM, Bóscolo FN, Santos AO, Camargo EE. Bone Scintigraphy 305 as an Adjunct for the Diagnosis of Oral Diseases. J Dent Educ. 2002;66(12):1381–7.
Schuepbach J, Dassonville O, Poissonnet G, Demard F. Early postoperative bone scintigraphy in the evaluation of microvascular bone grafts in head and neck reconstruction. Head Face Med. 2007;3(1):1–6.
O’Ryan FS, Khoury S, Liao W, Han MM, Hui RL, Baer D, et al. Intravenous Bisphosphonate-Related Osteonecrosis of the Jaw: Bone Scintigraphy as an Early Indicator. J Oral Maxillofac Surg. 2009;67(7):1363–72.
Chronopoulos A, Zarra T, Ehrenfeld M, Otto S. Osteoradionecrosis of the jaws: definition, epidemiology, staging and clinical and radiological findings. A concise review. Int Dent J. 2018;68(1):22–30.
Hricak H, Choi BI, Scott AM, Sugimura K, Muellner A, Von Schulthess GK, et al. Global trends in hybrid imaging. Radiology. 2010;257(2):498–506.
O'Ryan FS, Khoury S, Liao W, Han MM, Hui RL, Baer D, et al. Intravenous bisphosphonate-related osteonecrosis of the jaw: bone scintigraphy as an early indicator. J Oral Maxillofac Surg 2009; 67(7):1363-72.
Chiandussi S, Biasotto M, Dore F, Cavalli F, Cova MA, Di Lenarda R. Clinical and diagnostic imaging of Table I: Summary of Nuclear Medicine imaging modalities, their radiopharmaceutical agents and clinical utility Modality Radiophamaceutical Clinical Utility (Dental)
Omami G, Tamimi D, Branstetter BF. Basic principles and applications of (18)F-FDG- PET/CT in oral and maxillofacial imaging: A
pictorial essay. Imaging Sci Dent 2014; 44(4):325-32.
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324(5930):1029-33.
Vorster M, Doruyter A, Brink A, Mkhize S, Holness J, Malan N et al. Appropriate indications for positron emission tomography/
computed tomography. SAMJ 2015; 106(1): 105-122.
Warburton G, Nikitakis NG, Roberson P, Marinos NJ, Wu T, Sauk JJ, et al. Histopathological and lymphangiogenic parameters in
relation to lymph node metastasis in early-stage oral squamous cell carcinoma. J Oral Maxillofac Surg 2007; 65(3):475-84.
Greenberg JS, El Naggar AK, Mo V, Roberts D, Myers JN. Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Implication for therapeutic decision making. Cancer 2003; 98(3):508-15.
Kim Y, Roh JL, Kim JS, Lee JH, Choi SH, Nam SY et al. Chest radiography or chest CT plus head and neck CT versus 18F-FDG PET/CT for detection of distant metastasis and synchronous cancer in patients with head and neck cancer. Oral Oncol. 2019:
; 88:109-14.
Rohde M, Nielsen AL, Johansen J, Sørensen JA, Nguyen N, Diaz A et al. Head-to-head comparison of chest x-ray/head and neck
MRI, chest CT/head and neck MRI, and 18F- FDG PET/CT for detection of distant metastases and synchronous cancer in oral, pharyngeal, and laryngeal cancer. Journal of Nuclear Medicine. 2017: 1;58(12):1919-24.
Kim SA, Roh JL, Kim JS, Lee JH, Lee SH, Choi SH et al. 18F-FDG PET/CT surveillance for the detection of recurrence in patients
with head and neck cancer. Eur J Cancer. 2017 :1; 72:62-70.
Driessen JP, Peltenburg B, Philippens ME, Huijbregts JE, Pameijer FA, de Bree R et al. Prospective comparative study of MRI including diffusion-weighted images versus FDG PET-CT for the detection of recurrent head and neck squamous cell carcinomas after (chemo) radiotherapy. Eur J Radiol. 2019:1; 111:62-7.
Daisne JF, Duprez T, Weynand B, Lonneux M, Hamoir M, Reychler H et al. Tumor volume in pharyngolaryngeal squamous
cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology. 2004 Oct;233(1):93-100.
Geets X, Tomsej M, Lee JA, Duprez T, Coche E, Cosnard Get al. Adaptive biological image-guided IMRT with anatomic and functional imaging in pharyngo-laryngeal tumors: impact on target volume delineation and dose distribution using helical tomotherapy. Radiotherapy and Oncology. 2007 Oct 1;85(1):105-15.
Moule RN, Kayani I, Moinuddin SA, Meer K, Lemon C, Goodchild K et al. The potential advantages of 18FDG PET/CT-based target
volume delineation in radiotherapy planning of head and neck cancer. Radiotherapy and Oncology. 2010 Nov 1;97(2):189- 93.
Berthon B, Evans M, Marshall C, Palaniappan N, Cole N, Jayaprakasam V et al. Head and neck target delineation using a novel PET automatic segmentation algorithm. Radiotherapy and Oncology. 2017;1;122(2):242-7.
Alongi P, Laudicella R, Desideri I, Chiaravalloti A, Borghetti P, Quartuccio N et al. Positron emission tomography with computed
tomography imaging (PET/CT) for the radiotherapy planning definition of the biological target volume: PART 1. Crit Rev Oncol Hematol. 2019;1; 140:74-9.
Subramaniam RM, Truong M, Peller P, Sakai O, Mercier G. Fluorodeoxyglucose– positron-emission tomography imaging of
head and neck squamous cell cancer. AJNR Am J Neuroradiol. 2010;1;31(4):598-604.
Sheikhbahaei S, Ahn SJ, Moriarty E, Kang H, Fakhry C, Subramaniam RM. Intratherapy or posttherapy FDG PET or FDG PET/CT for patients with head and neck cancer: a systematic review and meta-analysis of prognostic studies. AJR Am J Roentgenol. 2015;205(5):1102-13.
Sheikhbahaei S, Taghipour M, Ahmad R, Fakhry C, Kiess AP, Chung CH, Subramaniam RM. Diagnostic accuracy of follow-up FDG PET or PET/CT in patients with head and neck cancer after definitive treatment: a systematic review and meta-analysis. AJR Am J Roentgenol. 2015;205(3):629-39.
Kim JW, Roh JL, Kim JS, Lee JH, Cho KJ, Choi SH et al. 18F-FDG PET/CT surveillance at 3–6 and 12 months for detection of recurrence and second primary cancer in patients with head and neck squamous cell carcinoma. Br J Cancer. 2013;109(12):2973-9.
Rusthoven KE, Koshy M, Paulino AC. The role of fluorodeoxyglucose positron emission tomography in cervical lymph node
metastases from an unknown primary tumor. Cancer.2004; 1;101(11):2641-9.
Goel R, Moore W, Sumer B, Khan S, Sher D, Subramaniam RM. Clinical practice in PET/CT for the management of head and neck squamous cell cancer. AJR Am J Roentgenol. 2017;209(2):289-303.
Szyszko TA, Cook GJ. PET/CT and PET/MRI in head and neck malignancy. Clinical radiology. 2018. Jan 1;73(1):60-9.
Olin AB, Hansen AE, Rasmussen JH, Ladefoged CN, Berthelesen AK, Hakansson K et al. Feasibility of multiparametric positron emission tomography/magnetic resonance imaging as a one-stop shop for radiation therapy planning for patients with head and neck cancer. International Journal of Radiation Oncology*Biology*Physics.2020 Dec1;108(5):1329-38.
Benson BW, Flint DJ, Liang H, Opatowsky MJ. Advances in diagnostic imaging for pathologic conditions of the jaws. Head
Neck Pathol 2014; 8(4):383-91.
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
.png){kind=spacer}