The description of diagnosed cases of oral epithelial dysplasia at the Tygerberg Oral Health Centre

Authors

DOI:

https://doi.org/10.17159/sadj.v79i10.19876

Keywords:

epidemiology, malignant

Abstract

Oral epithelial dysplasia (OED) is a growth anomaly which occurs due to atypical proliferation, change in the architectural 
and cytological features of cells of epithelial origin, resulting in the formation of a lesion with disturbed differentiation and 
maturation. The purpose of this study was to describe the OED cases diagnosed at Tygerberg Hospital in a seven-year period (from 
2012 until 2019) and to determine the demographics and clinical location of these cases. The patients’ medical records from the National Health Laboratory Service (NHLS) were reviewed. All diagnosed cases of OED were identified, and the data retrieved for further assessment and comparison.

Downloads

References

WHO. WHO classification of head and neck tumours. 4th ed. USA: International Agency for Research on Cancer; 2017.

Tilakaratne WM, Jayasooriya PR, Jayasuriya NS, De Silva RK. Oral epithelial dysplasia: Causes, quantification, prognosis, and management challenges. Periodontol 2000. 2019;80:126-47. DOI: https://doi.org/10.1111/prd.12259

Singh S, Singh J, Chandra S, Samadi FM. Prevalence of oral cancer and oral epithelial dysplasia among North Indian population: A retrospective institutional study. J Oral Maxillofac Pathol. 2020;24(1):87-92. DOI: https://doi.org/10.4103/jomfp.JOMFP_347_19

Hsue SS, Wang WC, Chen CH, Lin CC, Chen YK, Lin LM. Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: A follow-up study based in a Taiwanese hospital. J Oral Pathol Med. 2007;36:25-9. DOI: https://doi.org/10.1111/j.1600-0714.2006.00491.x

Pereira JS, Carvalho MV, Henriques AC, de Queiroz Camara TH, Miguel MC, Freitas RA. Epidemiology and correlation of the clinicopathological features in oral epithelial dysplasia: analysis of 173 cases. Ann Diagn Pathol. 2011;15:98-102. DOI: https://doi.org/10.1016/j.anndiagpath.2010.08.008

Sathiasekar AC, Mathew DG, Jaish Lal MS, Arul Prakash AA, Goma Kumar KU. Oral field cancerization and its clinical implications in the management in potentially malignant disorders. J Pharm Bioallied Sci. 2017; Suppl 1:S23-5. DOI: https://doi.org/10.4103/jpbs.JPBS_109_17

Ranganathan K, Kavitha L. Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders. J Oral Maxillofac Pathol. 2019;23:19-27. DOI: https://doi.org/10.4103/jomfp.JOMFP_13_19

Jaber MA. Oral epithelial dysplasia in non-users of tobacco and alcohol: an analysis of clinicopathologic characteristics and treatment outcome. J Oral Sci. 2010;52(1):13-21. DOI: https://doi.org/10.2334/josnusd.52.13

Khoury ZH, Sultan M, Sultan AS. Oral epithelial dysplasia grading systems: A systematic review & meta-analysis. Int J Surg Pathol. 2022;30(5):499-511. DOI: https://doi.org/10.1177/10668969211070171

Sathasivam HP, Sloan P, Thomson PJ, Robinson M. The clinical utility of contemporary oral epithelial dysplasia grading systems. J Oral Pathol Med. 2022;51:180-7. DOI: https://doi.org/10.1111/jop.13262

Odell M, Kujan E, Warnakulasuriya S, Sloan P. Oral epithelial dysplasia: Recognition, grading and clinical significance. Oral Dis. 2021;27:1947-76. DOI: https://doi.org/10.1111/odi.13993

Statistics South Africa. Cancer in South Africa, 2008–2019 (Report No. 03-08-00).

Dietrich T, Peter AR, Christian S. Clinical risk factors of oral leukoplakia in a representative sample of the US population. Oral Oncol. 2004;40(2):158‐62. DOI: https://doi.org/10.1016/S1368-8375(03)00145-3

Li L, Psoter WJ, Buxo CJ, Elias A, Cuadrado L, Morse DE. Smoking and drinking in relation to oral potentially malignant disorders in Puerto Rico: a case control study. BMC Cancer. 2011;11:324. DOI: https://doi.org/10.1186/1471-2407-11-324

Farshadpour F, Hordijk GJ, Koole R, Slootweg PJ. Non-smoking and non-drinking patients with head and neck squamous cell carcinoma: a distinct population. Oral Dis. 2007;13:239-43. DOI: https://doi.org/10.1111/j.1601-0825.2006.01274.x

Wey PD, Lotz MJ, Triedman LJ. Oral cancer in women non-users of tobacco and alcohol. Cancer. 1987;60:1644-50. DOI: https://doi.org/10.1002/1097-0142(19871001)60:7<1644::AID-CNCR2820600737>3.0.CO;2-E

Davidson CL, Richter KL, Van der Linde M, Coetsee J, Boy SC. Prevalence of oral and oropharyngeal human papillomavirus in a sample of South African men: a pilot study. S Afr Med J. 2014;104(5):358-61. DOI: https://doi.org/10.7196/SAMJ.7542

Wood NH, Motloba PD, Makwakwa LN, Bogers JP. Oral and oropharyngeal HPV prevalence in South Africa: A systematic review and meta-analysis. S Afr Dent J. 2021;76(10). DOI: https://doi.org/10.17159/2519-0105/2021/v76no10a8

Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009;45:309-16. DOI: https://doi.org/10.1016/j.oraloncology.2008.06.002

Cannon RB, Sowder LO, Buchmann JP, Hitchcock S, Lloyd S. Increasing use of non-surgical therapy in advanced-stage oral cancer: A population-based study. Head Neck. 2017;39(1):82-91. DOI: https://doi.org/10.1002/hed.24542

Warnakulasuriya S, Kerr AR. Oral cancer screening: Past, present, and future. J Dent Res. 2021;100(12):1313-20. DOI: https://doi.org/10.1177/00220345211014795

Lingen MW, Abt E, Agrawal N, Chaturvedi AK, Cohen E, D’Souza G, et al. Evidence-based clinical practice guideline for the evaluation of potentially malignant disorders in the oral cavity. J Am Dent Assoc. 2017;148(10):712-27. DOI: https://doi.org/10.1016/j.adaj.2017.07.032

Warnakulasuriya S, Chen THH. Areca nut and oral cancer: Evidence from studies conducted in humans. J Dent Res. 2022;101(10):1139-46. DOI: https://doi.org/10.1177/00220345221092751

Downloads

Published

2025-02-06

How to Cite

Nkomo, N. C., Jeftha, A., Kimmie-Dhansay, F., & Opperman, J. (2025). The description of diagnosed cases of oral epithelial dysplasia at the Tygerberg Oral Health Centre. South African Dental Journal, 79(10), 532. https://doi.org/10.17159/sadj.v79i10.19876

Most read articles by the same author(s)